Blar i forfatter "Fischer, Steffen"

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    • Development of 8f-labeled radiotracers for pet imaging of the adenosine a2a receptor: Synthesis, radiolabeling and preliminary biological evaluation 

      Lai, Thu Hang; Schröder, Susann; Toussaint, Magali; Dukić-Stefanović, Sladjana; Kranz, Mathias; Ludwig, Friedrich-Alexander; Fischer, Steffen; Steinbach, Jörg; Deuther-Conrad, Winnie; Brust, Peter; Moldovan, Rareş-Petru (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
      The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A<sub>2A</sub>R-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ...

    • Sigma-1 receptor positron emission tomography: A new molecular imaging approach using (S)-(-)-[18F]fluspidine in glioblastoma 

      Toussaint, Magali; Deuther-Conrad, Winnie; Kranz, Mathias; Fischer, Steffen; Ludwig, Friedrich-Alexander; Juratli, Tareq A.; Patt, Marianne; Wünsch, Bernhard; Schackert, Gabriele; Sabri, Osama; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is involved in signaling pathways assumed to control the proliferation of cancer cells and thus could serve as candidate for molecular characterisation of ...